Khan, 32, challenges pound-for-pound star Crawford, 31, for the American’s WBO welterweight world title on April 20 in the US.
The Bolton man has told how he couldn't resist a shot at Crawford's title instead of taking on Brook, 32, but had claimed the long-awaited domestic grudge match could still happen in the future.
However, in a drastic U-turn, Khan has now told FightHype that his wife Faryal Makhdoom desperately wants him to quit after his April showdown.
Khan said: “My wife’s always saying ‘you should retire’. I think this will probably be my last chapter in boxing now, I’ll give it a couple of fights – I feel like a couple of fights and I want to call it a day.
“I’ve had a great career honestly and I think to top it off with this win – I win this fight I can call it a day, I never want to finish on a loss, I always want to finish on a win on a high.
“I win this fight I might call it a day, you never know.
“Anything can happen in boxing because it’s not the money, it’s achieving everything I wanted to achieve in the sport then calling it a day then enjoying my life.”
Hopes of that long-awaited clash against Brook have taken a further blow after Khan suggested he has Manny Pacquiao lined up as another potential final opponent.
The two were sparring partners in Freddie Roach’s Wildcard Boxing Club, and have been regularly linked with a fight against each other.
Pacquiao defends his WBA strap against Adrien Broner on Saturday, and Khan revealed the possibility of boxing the Filipino boxing icon in Saudi Arabia excites him.
Khan said: “I would love that fight and now there’s talks like in places like Saudi Arabia, there’s talk all around the world that they want to see that fight, so I’m happy to take that fight to Saudi.”
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