The three heavyweights have each been linked in the past but his comments could spell bad news.
It is fair to say Isco is not enjoying his time at Real Madrid at the moment.
New boss Santiago Solari does not see eye-to-eye with the Spanish star and has not started him in any of his seven matches in charge.
And with a January move a strong possibility, the Premier League powerhouses could look to swoop in for the player who has excelled on the international stage far more than for Los Blancos.
Unai Emery's Arsenal is likely to be the best-suited destination.
Emery is of course Spanish while Isco came through the youth ranks at Valencia and was handed his first-team debut by the now-Gunners boss.
On the pitch, too, the playmaker would surely fit into Emery's style and plans.
The three players who usually occupy the No10 role at the Emirates are all either failing to deliver or expected to leave – Mesut Ozil, Aaron Ramsey and Henrikh Mkhitaryan.
It means a space could well be opened up in front of the sensational Lucas Torreira and his midfield partner Granit Xhaka.
Chelsea could be another option for Isco as Maurizio Sarri looks to deliver a Premier League title in his first season.
The Real Madrid ace could slot into a midfield already brimming with talent – but that could mean reduced game time for English pair Ross Barkley, Ruben Loftus-Cheek and maybe even N'Golo Kante.
He would also be an option in attack and was often deployed on the right flank by Julen Lopetegui and his predecessor Zinedine Zidane.
And with Eden Hazard on the other side, it could be devastating for opposition defences – that is if the Belgian star does not go to the Bernabeu.
Sara Salamo: Isco’s gorgeous Wag is a major movie star who has appeared opposite Penelope Cruz
The Real Madrid ace has struggled for minutes this season, as Los Blancos have endured an indifferent start to the season.
However, this year his Wag – the incredibly beautiful Sara Salamo – has had her defining moment in her chosen profession.
Tenerife-born Salamo, 26 just appeared alongside Oscar winners Penelope Cruz and Javier Bardem in Spanish movie, Everybody Knows.
The film, that was released back in September, was her biggest role yet and it could lead to her breaking Hollywood.
However, her career began on the small screen when she appeared on soap opera Arrayan when she was 18.
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Although Arsenal and Chelsea would be the favourites, Tottenham will be interested in a surprise move, too.
But what would that mean for the players who start behind Harry Kane in Mauricio Pochettino's line-up, especially Dele Alli?
Speaking ahead of the Champions League final this year, though, Isco admitted there have been opportunities to move to the Premier League but it has never even crossed his mind.
He said: "I have never thought about going to England. There’s been serious offers but I've never come close to moving to the Premier League.
"But I think I made the right choice to stay, my Champions League medals prove that."
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