The Belgian was sidelined with another knee injury at the start of November – less than two weeks after coming back from a two months out.
City initially said he would be out for four to six weeks but KdB is already making good progress.
He has pin-pointed a return to action around a week after the international break – meaning he could feature against Bournemouth on December 1.
And that would give the £54 million Belgian time to be fully firing for the trip to Stamford Bridge seven days later.
De Bruyne was City's player of the year in their record breaking season last year – but has yet to start a Premier League game this term.
Meanwhile City will run checks on striker Sergio Aguero who was substituted in the second half of the Manchester derby win over United.
The Argentina forward later had strapping at the top of his leg with some suggestion he had a tight hamstring.
But the champions do not play again until November 24 so they will be confident their top scorer will recover in time.
City are making changes in their medical department as long-serving physio Lee Nobes is leaving the Etihad to join Liverpool.
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