Eddie Jones' side are still smarting from their Six Nations disaster, which saw them finish fifth following three straight defeats.
England did beat the Springboks last time the teams played in June, but were beaten 2-1 by Rassie Erasmus' side overall in a disappointing summer tour.
What TV channel is England vs South Africa on and can I live stream it?
YOU can catch the game live on Sky Sports Action and Main Event.
Coverage from Twickenham begins at 2.30pm.
Use your Sky Go app to stream the action, whilst non-Sky subscribers can grab a NOW TV from £7.99 to watch on their tablet, mobile or laptop.
What time is kick-off?
THIS opening game of the autumn period is set for Saturday, November 3.
Kick-off is at 3pm, or 5pm in South Africa.
It's two years since the Springboks played England at Twickenham, when the hosts ran out 37-21 winners.
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