Dozens of firefighters are tackling the blaze at the Butt Lane landfill site in Milton, Cambs after it broke out about 6am.
The site is where RAF serviceman Corrie McKeague is thought by police to have ended up after climbing into a bin while on a night out with friends.
Cambridgeshire Fire and Rescue Service tweeted: "Crews were called at just after 6am this morning to the fire on Butt Lane in Milton.
"A large amount of household waste and machinery are involved in the fire."
The service later tweeted: "Around 40 firefighters are currently tackling a fire in #Milton near #Cambridge.
"Residents in the area are advised to keep their doors and windows closed due to the smoke."
Pictures posted on social media by the fire service show flames rising up from the ground, with large plumes of black smoke filling the sky around it.
McKeague was last seen on a night out with friends in Bury St Edmunds, Suffolk, in September 2016.
The body of RAF gunner Corrie McKeague is thought to be buried in a Suffolk landfill.
It will likely never be recovered due to the amount of rubbish on site.
Detectives believe he could have been crushed by a waste lorry after falling asleep in a bin.
Police believe Corrie is buried at the site after CCTV showed a Biffa waste lorry making a collection in the area Corrie had last been seen at 3.25am in Bury St Edmonds.
Cops originally said a search of the landfill would take just six to ten weeks.
But specialist officers shifted more than 4,430 tonnes of rubbish over a four month period – without finding any trace of him.
On August 30, McKeague's mother Nicola Urquhart made the shocking new claim that her son didn't climb into the bin and was not in landfill.
The 49-year-old alleged a lack of CCTV in the hours after he vanished meant the airman could have walked or been driven out of the area he was last seen in.
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