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Oprah Winfrey<\/strong> is overcoming decades of shame attached to her body, and she’s admitting taking weight-loss medication … even though she previously said she’d never do that to slim down.<\/p>\n After shedding 40 lbs this year, the billionaire TV mogul is done with cruel and insensitive conversations about her appearance — gushing that pharmaceutical assistance has changed her relationship with her figure.<\/p>\n Waiting for your permission to load the Instagram Media.<\/p>\n Oprah tells PEOPLE a doctor prescribed the meds to her following her “Life You Want” series’ “The State Of Weight” taping back in July, where she realized she wasn’t to blame for being overweight … noting it was more about the brain than willpower.<\/p>\n With a new mindset, Oprah says weight-loss meds are a healthier alternative for her rather than yo-yo-ing, and she takes the medically-approved drug as, and when, needed.<\/p>\n Waiting for your permission to load the Instagram Media.<\/p>\n Case in point, she took them just before Thanksgiving cause she knew she had “two weeks of solid eating” … and, as a result, says she only gained half a pound rather than eight.<\/p>\n